The Science for Africa Foundation (SFA Foundation) has launched the second phase of a multimillion-dollar programme developing world-class research and African scientific leaders on the continent, while strengthening African institutions. The second phase of the Developing Excellence in Leadership, Training, and Science in Africa (DELTAS Africa) programme provides $70M through the joint funding support of Wellcome and the UK’s Foreign, Commonwealth & Development Office (FCDO). DELTAS Africa II funds 14 consortia in nine African countries, with partnerships and networks across the globe, to produce quality scientific data and information for evidence-based decision making generated by world class science leaders working in conducive and enabling environments. It also drives the development of a critical mass of globally competitive research leaders.